Medicines

Albendazole dose for kids in worm infestation – The Miracle Anthelmintic

Albendazole dose for kids Posted On
Posted By SUMIT SHARMA

Introduction

Do you know the right dose of Albendazole in kids?

You generally use this medicine but don’t know the exact dose. Today, I will tell you the proper albendazole dose for kids in different worm infestations.

In your body, the gastrointestinal tract is the house for many worms. They need food to survive. These worms take food from your intestine and reproduce quickly.

Worm infestation can spread to anyone, but it is more prevalent in children who live in a soil area or live in an unhygienic environment, eat without washing their hands, play with pets like cats and dogs. 

Generally, all worms are parasites. In medical terms, they knowns as helminths. If you get worms infection, it would say Helminthiasis.

Albendazole is an anthelmintics drug that either kills or expels the worms from your intestine. 

Although, Helminthiasis is rarely deadly, but it frequently makes your health ill.

The purpose of this article is to provide an accurate dose of Albendazole to your kids. 

This article will discuss how to take the exact albendazole dose for kids like infants (1-2 years), toddlers/preschool (2-3 years), and school-aged children (more than 3 years).

But before that, we grab some basic information on worms and Albendazole.  

What do worms do to humans? 

There are certain worms that most commonly cause infections in our stomach and intestine – 

  • Round worm (ascaris lumbricoides, strongyloides)
  • Hookworm (ancylostoma duodenale and necator americanus)
  • Pinworm or threadworm (enterobius vermicularis)
  • Whipworm (trichuris trichiura)
  • Tapeworm (taenia species)

If these worms enter your gastrointestinal tract, they get energy in the form of glucose. As a result, these worms get start to multiply. 

Among these worms, Pinworm or threadworm is the most common parasite which causes infestation in kids.

During pinworm infestation, these worms are present in your kid’s intestine. They crawl around the anal opening through the rectum and lay their eggs. 

Due to this, your kids may get itching in that area. 

In girls, it may spread around the vagina and cause vaginal itching.

 

How do you know if you have worms in your stomach?

You may have experienced the following symptoms of worms in the stomach – 

  • Abdominal pain
  • Nausea or vomiting 
  • Diarrhea
  • Small and white worms in stool
  • Severe itching around your anus, especially at night
  • Loss of weight 
  • Loss of appetite
  • Blood in stool
  • Fatigue

 

Sometimes, your child may do teeth grinding. During this condition, your child may also have an abnormal craving for eating inedible foods like chalk, clay, paper, ashes, etc. This eating disorder is called Pica

 

What is Albendazole, and how does Albendazole work in the body?

Albendazole is a prescription medication used to treat infections caused by a type of worm called a helminth. 

This drug belongs to a group of medicines called anthelmintics. It is a broad-spectrum anthelmintic of benzimidazole class that is designed to treat worms.

When you take this drug, it enters your intestine and binds on the parasite’s microtubular protein “β-tubulin.” 

Due to binding on tubulin, it inhibits the polymerization process (or multiplication) of worms. 

Moreover, Albendazole stops the process of glucose uptake in the parasite and reduces its glycogen stores.

In this way, the albendazole drug kills the worms and evacuates their dead bodies through stool. 

 

Is Albendazole safe for toddlers (1-3 years old child)?

According to WHO (World Health Organisation), Albendazole medicine is generally recommended as preventive chemotherapy (deworming) in children because children are more at risk of worm infection. 

A single dose of Albendazole is usually recommended to every child who lives in a slum or unhygienic area. 

You may give this drug to your child every year or every 6 months under medical supervision. 

It is a highly effective and well-tolerated drug among children over 1 year. 

A review article published in Cambridge University Press 2001 summarised the safety and efficacy of Albendazole in humans. 

In this study, it was found Albendazole is absolutely safe in children and adults.

It has very low or negligible side effects. Moreover, Albendazole is easy to administer because Albendazole requires only single-dose administration. 

 

How much albendazole tablet dose for a child for deworming?

Albendazole is available in the form of tablets and syrup. You may give either tablet or syrup (suspension) to your child as per their feasibility. It comes in the market with a brand name of 

  • Zentel
  • Noworm
  • Bandy
  • Bendex

Albendazole dose for kids

 

Albendazole dose for kids

 

Albendazole dose for kids

Albendazole dose for child

1. Albendazole dose for infants (less than 1 year)

Albendazole is usually not recommended in infants (less than 1 year) because we don’t have enough safety data in this age group. 

 

2. Albendazole dose for 1 to 2-year child

According to WHO, the albendazole 200 mg dose is recommended for children in age group 1-2 years. 

A single dose is sufficient to treat worm infestations. 

If the symptoms are not subsided, then the same dose can be repeated after 2 weeks.   

 

3. Albendazole dose for above 2 years child

If your child’s age is more than 2 years, like pre-schoolers (2-5 years), school-aged children (6-12 years), and teenagers (>12 years). Then albendazole 400 mg single dose is sufficient for treating worm infestations. 

If the condition is not controlled well, then the same dose can be repeated after 2 weeks. 

In 2006, a randomized controlled trial was conducted in Uganda associated with deworming with increased weight gain after taking the standard dose of Albendazole 400 mg in preschool children over three consecutive years. 

 

Albendazole dose for adults and older

Albendazole 400 mg is the standard dose, and a single dose is quite enough for deworming. It can be given in any age group, either adult or older.  

 

What to do if pinworms keep coming back?

Suppose your kids are not getting a response from Albendazole even after administering the second dose. In that case, your doctor may give you ivermectin medicine with Albendazole

Ivermectin paralyzes or kills the worms and expels them through stool. It is a potent anthelmintic agent that helps kill and clear your intestinal worms. 

The combination of ivermectin and Albendazole is usually prescribed in recurrent or repeated worm infestation. The combination of these drugs is available in the market with common brands – 

  • Noworm plus
  • Bandy plus

Albendazole dose for kids

  • Bendex plus
  • Ivoral forte 
  • Ibendzole 

Albendazole dose for kids

 

A single dose of ivermectin is enough, and the dose can be repeated if the worm load is very high. 

It is a safe and effective combination. Even a study published in The Lancet, 2021, has proven the high efficacy of co-administered ivermectin-albendazole over monotherapy of Albendazole.  

 

What would be the exact albendazole syrup dose for children? 

Albendazole medicine usually comes in a suspension dosage form. 

These dosage forms contain the suspended particles of the albendazole drug in a 10 ml bottle. Whereas, Albendazole particles are completely dissolved in syrup preparation. 

So, we are generally required to shake the albendazole suspension bottle before use. 

To avoid confusion, people sometimes called it syrup.

The entire 10 ml bottle of albendazole contains 400 mg. It means each 5ml of albendazole suspension contains 200 mg of albendazole drug. 

albendazole dose for kids

The amount and strength of albendazole syrup (or suspension) for a child are based on their weight (15 mg/kg).

Assume your child is 1–2 years old and weighs between 10 and 12 kilograms. To calculate albendazole dosage, we would need (15 x 10 to 12) 150 to 180 mg.

But it is generally considered 200 mg albendazole standard dose for less than 2 years children. In this case, the albendazole syrup dose for 1 to 2-year-old children will be 5 ml.

But if the child is older than 2 years, you’ll have to give them a full bottle (10 ml) of albendazole syrup.

For example –

Age groups Albendazole dose in mgAlbendazole dose in ml
 

Albendazole syrup dose for 3 year old child

 

400 mgEntire 10 ml bottle
Albendazole syrup dose for 4 year old child

 

400 mgEntire 10 ml bottle
Albendazole syrup dose for 5 year old

 

400 mgEntire 10 ml bottle
Albendazole syrup dose for 6 year old400 mgEntire 10 ml bottle
Albendazole syrup dose for 7 year-old

 

400 mgEntire 10 ml bottle

 

Albendazole oral suspension comes in different brand names such as Zentel, Abendol, Bandy, Bendex, Noworm, ABZ, etc. Among these, Zentel and Bandy are the most popular brand in India.

 

What is the best time to take Albendazole for deworming?

The best time to take an albendazole tablet or syrup is at bed time because worms are generally more active during the night. 

It is always better to take Albendazole with a fatty meal (high-fat content) like milk, paneer, cheese, etc. The absorption of the albendazole drug increases five times more if you take a fatty meal. 

Albendazole may be given on an empty stomach in some worm infestation. 

 

How to use albendazole tablets or syrup in different parasitic infections?

Although albendazole 400 mg is considered the standard dose for children above 2 years in most worm infections like – 

  • Hookworm disease (ancylostomiasis and necatoriasis)
  • Roundworm infection (ascariasis)
  • Whipworm infection (trichuriasis)
  • Threadworm infection (strongyloidiasis) 
  • Pinworm infection (enterobiasis) 
  • Giardia infection (giardiasis in children)

 

However, the dose of albendazole may vary in certain worm infection like Cystic hydatid disease and Neurocysticercosis. 

A cystic hydatid infection is generally caused by larvae of dog tapeworm. It mainly affects your liver, lungs, and stomach.

Whereas neurocysticercosis infection is caused by larvae of the pork tapeworm. It mainly affects your brain and spinal cord area. 

Here, albendazole is considered a drug of choice in Cystic hydatid disease and Neurocysticercosis

The dosing of albendazole in these conditions is entirely different.

If you have cystic hydatid disease, you need to take albendazole 400 mg twice for 28 days in 3 cycles of treatment, followed by a 14-day washout period. 

For children, the dose will be calculated as 15mg/kg per body weight.

In Neurocysticercosis, albendazole 400 mg twice daily with meals for 8 to 30 days. It can be repeated as necessary.

 

What drugs interact with Albendazole?

Albendazole does not cause any severe reaction with other drugs. But some medicines may interfere with the efficacy of Albendazole. 

Drugs that decrease the efficacy of Albendazole

Your doctor may increase the dose of Albendazole if you or your children are on antiepileptics drugs like phenytoin, carbamazepine, and phenobarbital

 

Drugs that increase the efficacy of Albendazole

Some drugs inhibit the metabolism of Albendazole. So, your doctor may decrease the dose of Albendazole if you or your children are taking the following medicines or foods – 

  • Cimetidine 
  • Corticosteroids like dexamethasone, 
  • Antiparasitic drugs like praziquantel and levamisole 
  • Grapefruit (by inhibiting albendazole metabolism)
  • Long term administration of antiretroviral drug – ritonavir 

 

Conclusion 

We have discussed about albendazole medication and the correct albendazole dose for kids in different age group in infants, toddlers/preschool aged children, school aged children, etc. 

Albendazole is a well-tolerated and highly effective anthelmintic drug in children and adults too. 

It is an absolutely safe drug as Albendazole has minimum side effects

The biggest advantage of the albendazole drug is single-dose administration because a single dose is sufficient for its effectiveness. So, there is no need to repeat the medicine. 

It is only an informative article. So, you should take this medicine under proper medical supervision because Albendazole is a schedule H drug (or prescription drug).

If you found this post informative. Please share it on social media. 

 

FAQ

Q 1. Can I take Paracetamol and albendazole together?

There is no such interaction between paracetamol and Albendazole. So, you may take these drugs together by consulting with your doctor. 

 

Q 2. Is it safe to take Albendazole during pregnancy?

Albendazole has shown embryotoxicity in animal studies. So, it should be avoided in pregnancy.

 

Q 3. Which is better albendazole or mebendazole?

Both drugs are well-tolerated and effective. But in many studies, Albendazole has shown more effectiveness than mebendazole. 

 

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